Ikeda K, Suzuki M, Ikebuchi M, Hara Y, Tsushima M, Yamamoto A, Harano Y
Division of Atherosclerosis, Metabolism, and Clinical Nutrition, National Cardiovascular Center, Osaka, Japan.
J Diabetes Complications. 1995 Oct-Dec;9(4):227-9. doi: 10.1016/1056-8727(95)80008-3.
The purpose of the present study was to elucidate the characteristic lipoprotein disorder in essential hypertension. Twenty-six patients with essential hypertension (HT) but without diabetes mellitus or obesity and 24 healthy subjects (control) were recruited into this study. Lipoproteins of HT and controls were separated by ultracentrifugation to very-low-density lipoprotein (VLDL), intermediate density lipoprotein (IDL), low-density liproprotein (LDL), and (HDL) fractions. Cholesterol and triglycerides were determined with enzyme assay, and apoB were determined by highly sensitive latex agglutination (Kyowa-hakko Co. LD). There was no difference in age (mean +/- SE; HT, 63 +/- 2 versus control, 60 +/- 2 years) or body-mass index (22.7 +/- 0.4 versus 21.7 +/- 0.5 kg/m2) between HT and controls. Blood pressure in HT and controls was 158 +/- 2/87 +/- 12 mm Hg and 123 +/- 3/72 +/- 2 mm Hg, respectively. Cholesterol did not change significantly in plasma (192.1 +/- 7.0 versus 176.4 +/- 4.2 mg/dL), VLDL (15.2 +/- 2.4 versus 11.8 +/- 1.7 mg/dL), IDL (14.8 +/- 2.4 versus 10.7 +/- 1.6 mg/dL), LDL (93.7 +/- 4.6 versus 83.1 +/- 3.9 mg/dL), nor in HDL (51.9 +/- 2.7 versus 58.1 +/- 3.2 mg/dL). Triglycerides (TG) increased in plasma (120.0 +/- 10.0 versus 87.5 +/- 9.3 mg/dL, p < 0.05), although TG did not change in all subfractions. ApoB increased in plasma (105.5 +/- 5.1 versus 85.6 +/- 3.6 mg/dL, p < 0.01), IDL (9.0 +/- 1.3 versus 5.4 +/- 0.6 mg/dL, p < 0.05), and LDL (76.3 +/- 4.3 versus 59.4 +/- 3.7 mg/dL, p < 0.01) in HT compared with controls. The ratio of cholesterol to apoB in LDL decreased (1.27 +/- 0.06 versus 1.48 +/- 0.08, p < 0.05). In essential HT, number of apoB containing lipoproteins (IDL, LDL) increased. Low ratio of cholesterol to apoB was noted in LDL, indicating the presence of small, dense LDL. As cholesterol in LDL was normal, hyperbetalipoproteinemia is also a characteristic disorder of essential HT.
本研究的目的是阐明原发性高血压患者特有的脂蛋白紊乱情况。本研究招募了26例无糖尿病或肥胖症的原发性高血压（HT）患者以及24名健康受试者（对照组）。通过超速离心法将HT患者和对照组的脂蛋白分离为极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）组分。采用酶法测定胆固醇和甘油三酯，通过高敏乳胶凝集法（协和发酵公司LD）测定载脂蛋白B。HT患者与对照组在年龄（平均值±标准误；HT组为63±2岁，对照组为60±2岁）或体重指数（分别为22.7±0.4与21.7±0.5kg/m²）方面无差异。HT患者和对照组的血压分别为158±2/87±12mmHg和123±3/72±2mmHg。血浆中胆固醇（192.1±7.0与176.4±4.2mg/dL）、VLDL（15.2±2.4与11.8±1.7mg/dL）、IDL（14.8±2.4与10.7±1.6mg/dL）、LDL（93.7±4.6与83.1±3.9mg/dL）以及HDL（51.9±
