Krolewski A S, Warram J H
Section on Epidemiology and Genetics, Joslin Diabetes Center, Boston, MA 02215, USA.
J Diabetes Complications. 1995 Oct-Dec;9(4):277-81. doi: 10.1016/1056-8727(95)80021-6.
Various types of evidence supporting the hypothesis of genetic susceptibility to diabetic kidney disease (DKD) are reviewed. Three groups of studies were distinguished: (1) epidemiologic and family studies, (2) studies of phenotypic markers/predictors, and (3) studies of DNA markers. Although all of these studies point to the existence of susceptibility to DKD, further research is required. Particularly needed are studies that examine the mechanisms of interaction between genetic susceptibility to DKD and poor glycemic control, and studies to identify specific molecular mechanisms underlying this susceptibility.
本文综述了支持糖尿病肾病（DKD）遗传易感性假说的各类证据。研究分为三组：（1）流行病学和家族研究；（2）表型标志物/预测指标研究；（3）DNA标志物研究。尽管所有这些研究都表明存在DKD易感性，但仍需进一步研究。特别需要开展研究，以探讨DKD遗传易感性与血糖控制不佳之间的相互作用机制，以及确定这种易感性背后的具体分子机制。
