Kiseleva I P, Lapin I P, Leont'ev V G, Prakh'e Samsonova M L
Vopr Med Khim. 1977 Jan-Feb(1):18-23.
After a single intraperitoneal administration lithium carbonate (50 and 100 mg per kg of body weight) caused an increase in the tryptophane pyrrolase activity in rat liver tissue by 50-80% within 5 hrs and did not affect the enzyme within 1, 3 and 20 hrs. Content of lithium was quite unaltered in rat blood serum after administration of lithium carbonate at a dose of 50 mg/kg; it slightly exceeded the therapeutic level at a dose of 100 mg/kg. Addition of the lithium preparation (7-10(-3)-7-10(-5) M) to liver homogenates did not change the tryptophane pyrrolase activity in vitro. The same doses of lithium (50 and 100 mg/kg) caused a 2.5-fold increase in content of 11-hydrocorticosteroids in rat blood plasma; the effect was prevented by previous administration of dexamethasone. In experiments with adrenalectomized rats lithium did not affect the enzymatic activity. Repeated administration of lithium (50 mg/kg) within 10 days did not affect the tryptophane pyrrolase activity and did not alter the content of 11-hydroxycorticosteroids in rat blood plasma. The data obtained suggest that the increase in the tryptophane pyrrolase activity, caused by lithium, is mediated through the elevation in content of 11-hydroxycorticosteroids in blood.
单次腹腔注射碳酸锂（每千克体重50毫克和100毫克）后，大鼠肝脏组织中的色氨酸吡咯酶活性在5小时内增加了50 - 80%，而在1小时、3小时和20小时内对该酶无影响。给予50毫克/千克剂量的碳酸锂后，大鼠血清中的锂含量未发生变化；给予100毫克/千克剂量时，锂含量略超过治疗水平。在肝匀浆中添加锂制剂（7×10⁻³ - 7×10⁻⁵ M）在体外并未改变色氨酸吡咯酶活性。相同剂量的锂（50毫克/千克和100毫克/千克）使大鼠血浆中11 - 氢化皮质类固醇含量增加了2.5倍；预先给予地塞米松可防止这种作用。在对肾上腺切除大鼠的实验中，锂对酶活性无影响。在10天内重复给予锂（50毫克/千克）不影响色氨酸吡咯酶活性，也不改变大鼠血浆中11 - 羟基皮质类固醇的含量。所获得的数据表明，锂引起的色氨酸吡咯酶活性增加是通过血液中11 - 羟基皮质类固醇含量的升高介导的。
