Jehn U, Pötscher C, Heinemann V
Med. Klinik III, Klinikum Grosshadern, University of Munich, FRG.
Leuk Lymphoma. 1995 Sep;19(1-2):153-7. doi: 10.3109/10428199509059670.
Six patients with either acceleration or blast crisis of transformed chronic myeloid leukemia (CML) were treated with high-dose interferon alpha in combination with hydroxyurea. All patients responded to the treatment by reversal to stable chronic phase. Two of these patients responded repeatedly during their course of disease. Median time for return to chronic phase was 4 weeks. Adverse side-effects such as nausea, vomiting, hairloss, fever, prolonged cytopenia were not observed.
6例转化型慢性髓性白血病（CML）加速期或急变期患者接受了大剂量干扰素α联合羟基脲治疗。所有患者经治疗后均逆转至稳定的慢性期。其中2例患者在病程中反复出现缓解。恢复至慢性期的中位时间为4周。未观察到恶心、呕吐、脱发、发热、长期血细胞减少等不良反应。
