Rasmussen M H, Jensen L T, Andersen T, Breum L, Hilsted J
Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark.
Int J Obes Relat Metab Disord. 1995 Sep;19(9):659-63.
To investigate the impact of obesity, fat distribution and weight loss on collagen turnover using serum concentrations of the carboxyterminal propeptide of type I procollagen (S-PICP) and the aminoterminal propeptide of type III pro-collagen (S-PIIINP) as markers for collagen turnover.
Blood samples were obtained once at baseline, and after 8 and 16 weeks of dietary treatment (5.0 MJ/day diet).
Outpatient clinic of Hvidovre University Hospital.
S-PICP, S-PIIINP, fat distribution and weight loss.
S-PIIINP was associated with body weight (r = 0.37; P = 0.004), height (r = 0.27; P = 0.04), waist circumference (r = 0.35; P = 0.007), as well as with WHR (r = 0.33; P = 0.01) and was inversely correlated to age (r = -0.40; P = 0.002). Compared with randomly selected controls from a large pool of healthy volunteers, the obese patients had elevated S-PIIINP values before as well as during weight loss, whereas S-PICP levels were within the normal range and did not correlate with any anthropometric measures. The average weight loss after 16 weeks dietary treatment was 8.1 kg (s.d. = 0.8). S-PIIINP decreased during the 16 weeks of energy restriction (P < 0.05) and changes in S-PIIINP was correlated to body weight loss (r = 0.32; P < 0.05) and to changes in waist circumference (r = 0.34; P < 0.05) as well as changes in WHR (r = 0.30; P < 0.05).
S-PIIINP is elevated in obesity and associated with body fat distribution, suggesting an increased turnover of type III collagen related to obesity in general and to abdominal obesity in particular. S-PIIINP levels decreases during weight loss in obese subjects, whereas S-PICP levels seems un-related to obesity and weight loss.
以血清I型前胶原羧基末端前肽（S-PICP）和III型前胶原氨基末端前肽（S-PIIINP）浓度作为胶原转换的标志物，研究肥胖、脂肪分布及体重减轻对胶原转换的影响。
在基线时、饮食治疗8周和16周后（5.0兆焦耳/天的饮食）采集血样。
维德夫勒大学医院门诊。
S-PICP、S-PIIINP、脂肪分布和体重减轻。
S-PIIINP与体重（r = 0.37；P = 0.004）、身高（r = 0.27；P = 0.04）、腰围（r = 0.35；P = 0.007）以及腰臀比（WHR，r = 0.33；P = 0.01）相关，且与年龄呈负相关（r = -0.40；P = 0.002）。与从大量健康志愿者中随机选取的对照组相比，肥胖患者在减肥前及减肥期间的S-PIIINP值均升高，而S-PICP水平在正常范围内，且与任何人体测量指标均无相关性。16周饮食治疗后的平均体重减轻为8.1千克（标准差 = 0.8）。在16周的能量限制期间，S-PIIINP降低（P < 0.05），S-PIIINP的变化与体重减轻相关（r = 0.32；P < 0.05），与腰围变化相关（r = 0.34；P < 0.05），也与WHR变化相关（r = 0.30；P < 0.05）。
肥胖患者的S-PIIINP升高，且与体脂分布相关，提示III型胶原转换增加与一般肥胖尤其是腹部肥胖有关。肥胖受试者减肥期间S-PIIINP水平降低，而S-PICP水平似乎与肥胖和体重减轻无关。
