Marotto P C, Michalany N S, Vilela M P, Mendes N F, Mendes E
Disciplina de Doenças Infecciosas e Parasitárias, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brasil.
J Investig Allergol Clin Immunol. 1995 Sep-Oct;5(5):269-71.
Cutaneous immediate and late phase reactions (LPR) to schistosomin were studied in 29 patients with schistosomiasis mansoni. In 12 of these patients, the determination of total and specific serum IgE by immunoenzymatic method against schistosome antigen was carried out using serum samples obtained on the same day as the cutaneous tests. Skin biopsies were taken from 4 typical LPRs. Immediate reactions occurred in all except one and LPRs in 12 (41.3%). Patients with positive cutaneous reactions had highe levels of specific serum IgE against schistosome antigen. Histopathological studies showed a moderate exudate consisting mainly of neutrophils (60%) and eosinophils (40%). LPRs in schistosomiasis have the same characteristics reported in the medical literature in relation to time of appearance, morphology and histopathology. The immunopathogenic role played by LPRs in the patients remains to be clarified.
对29例曼氏血吸虫病患者的皮肤即刻和迟发相反应（LPR）进行了研究。在其中12例患者中，使用与皮肤试验同一天采集的血清样本，通过免疫酶法测定了针对血吸虫抗原的总血清IgE和特异性血清IgE。从4例典型的LPR中进行了皮肤活检。除1例患者外，所有患者均出现即刻反应，12例（41.3%）出现LPR。皮肤反应阳性的患者针对血吸虫抗原的特异性血清IgE水平较高。组织病理学研究显示有中度渗出物，主要由中性粒细胞（60%）和嗜酸性粒细胞（40%）组成。血吸虫病中的LPR在出现时间、形态和组织病理学方面具有医学文献中报道的相同特征。LPR在这些患者中所起的免疫致病作用仍有待阐明。
