Zhang S, Liu J, He L
Institute of Basic Medical Sciences, CAMS, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Aug;17(4):254-8.
Surgery of brain injury was established in rats with medial frontal cortex lesion or acute cerebral ischemia and reperfusion. Learning and memory deficits were induced. These rats can be served as the animal model of dementia. Intraperitoneal injection of 654-2 (30 mg/kg per day) started from the day of surgery until a total of 10 shots were given. We first reported that 654-2 improved the deficits of learning and memory in avoidance response of rats after the two types of brain damage. Further more, the results showed that 654-2 enhanced SOD activity and inhibited the elevation of superoxides (MDA) in forebrain of cortex-lesioned rats. results suggest that 654-2 probably has the effect of protection of the brain cell against the injury of free radicals.
脑损伤手术在患有内侧额叶皮质损伤或急性脑缺血再灌注的大鼠中进行。诱导学习和记忆缺陷。这些大鼠可作为痴呆动物模型。从手术当天开始腹腔注射654-2（每天30mg/kg），共注射10次。我们首次报道，654-2改善了两种脑损伤后大鼠回避反应中的学习和记忆缺陷。此外，结果表明，654-2增强了皮质损伤大鼠前脑的超氧化物歧化酶（SOD）活性，并抑制了超氧化物（丙二醛，MDA）的升高。结果表明，654-2可能具有保护脑细胞免受自由基损伤的作用。
