Uemasu J, Munemura C, Fujihara M, Kawasaki H
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Clin Nephrol. 1995 Oct;44(4):225-30.
The effect of prostaglandin E1 (PGE1) on renal function was examined in 8 patients with autosomal dominant polycystic kidney disease (ADPKD) and 8 subjects with non-polycystic chronic renal disease (CRD). Intravenous PGE1 infusion (50 micrograms/hr, for 2 hrs) resulted in a significant fall in creatinine clearance in ADPKD, but not in CRD. Although PGE1 had no effect on urinary sodium excretion and osmolar clearance in both groups, it increased significantly free water clearance in CRD, but not in ADPKD. Nephrogenic cyclic AMP during PGE1 administration did not differ significantly from their respective baseline level in two groups. In these groups, although nephrogenic cyclic AMP correlated poorly with urine volume, osmolar clearance, and free water clearance, it demonstrated a significant negative correlation with creatinine clearance. Renal volume in ADPKD cases had no relation with the parameters of renal function examined during PGE1 infusion. These data demonstrate the different responses of polycystic kidneys to PGE1 compared with non-polycystic kidneys.
研究了前列腺素E1（PGE1）对8例常染色体显性多囊肾病（ADPKD）患者及8例非多囊性慢性肾病（CRD）患者肾功能的影响。静脉输注PGE1（50微克/小时，持续2小时）导致ADPKD患者的肌酐清除率显著下降，但CRD患者未出现此情况。虽然PGE1对两组患者的尿钠排泄和渗透清除率均无影响，但它使CRD患者的自由水清除率显著增加，而ADPKD患者未出现此情况。在给予PGE1期间，两组患者的肾源性环磷酸腺苷（cAMP）与其各自的基线水平相比无显著差异。在这些组中，虽然肾源性cAMP与尿量、渗透清除率和自由水清除率的相关性较差，但它与肌酐清除率呈显著负相关。ADPKD患者的肾体积与PGE1输注期间所检测的肾功能参数无关。这些数据表明，与非多囊肾相比，多囊肾对PGE1的反应不同。
