催产素可增强生殖功能正常的母马和易患子宫内膜炎的母马子宫腔内放射性胶体的清除。

Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis.

作者信息

LeBlanc M, Neuwirth L, Mauragis D, Klapstein E, Tran T

机构信息

Department of Large Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville 32610, USA.

出版信息

Equine Vet J. 1994 Jul;26(4):279-82. doi: 10.1111/j.2042-3306.1994.tb04387.x.

DOI:10.1111/j.2042-3306.1994.tb04387.x

PMID:8575394

Abstract

The effects of oxytocin on the percentage of technetium 99m albumin colloid (99mTc-microAA), cleared from the uterine lumen was measured in 13 mares. Scintigraphy was performed during 4 consecutive oestrous cycles, on Day 3 of oestrus during Cycles one and 3 and 48 h after ovulation during Cycles 2 and 4. Oxytocin (20 iu) was given i.v. after the initial scintigraphy image during Cycles 3 and 4. Seven multiparous mares (Group 1) were classified as 'susceptible' and 6 mares (2 nulliparous and 4 multiparous; Group 2) were classified as 'resistant' to endometritis. All mares cleared > 90% of 99mTc-microAA within 30 min of oxytocin injection. When no drug was given, Group 1 mares cleared negligible amounts of radiocolloid (< 5%) and Group 2 mares cleared 50-80%. No mares showed signs of colic after oxytocin administration. It is concluded that oxytocin enhances uterine clearance of radiocolloid and may be useful for treating mares exhibiting impaired uterine clearance.

摘要

在13匹母马中测量了催产素对从子宫腔清除的99m锝白蛋白胶体（99mTc - microAA）百分比的影响。在连续4个发情周期进行闪烁扫描，在第1和第3周期的发情第3天以及第2和第4周期排卵后48小时进行。在第3和第4周期的初始闪烁扫描图像后静脉注射催产素（20国际单位）。7匹经产母马（第1组）被归类为对子宫内膜炎“敏感”，6匹母马（2匹初产和4匹经产；第2组）被归类为对子宫内膜炎“抵抗”。所有母马在注射催产素后30分钟内清除了> 90%的99mTc - microAA。当未给药时，第1组母马清除的放射性胶体量可忽略不计（< 5%），第2组母马清除50 - 80%。催产素给药后没有母马出现绞痛迹象。结论是催产素可增强子宫对放射性胶体的清除，可能有助于治疗子宫清除功能受损的母马。