LeBlanc M, Neuwirth L, Mauragis D, Klapstein E, Tran T
Department of Large Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville 32610, USA.
Equine Vet J. 1994 Jul;26(4):279-82. doi: 10.1111/j.2042-3306.1994.tb04387.x.
The effects of oxytocin on the percentage of technetium 99m albumin colloid (99mTc-microAA), cleared from the uterine lumen was measured in 13 mares. Scintigraphy was performed during 4 consecutive oestrous cycles, on Day 3 of oestrus during Cycles one and 3 and 48 h after ovulation during Cycles 2 and 4. Oxytocin (20 iu) was given i.v. after the initial scintigraphy image during Cycles 3 and 4. Seven multiparous mares (Group 1) were classified as 'susceptible' and 6 mares (2 nulliparous and 4 multiparous; Group 2) were classified as 'resistant' to endometritis. All mares cleared > 90% of 99mTc-microAA within 30 min of oxytocin injection. When no drug was given, Group 1 mares cleared negligible amounts of radiocolloid (< 5%) and Group 2 mares cleared 50-80%. No mares showed signs of colic after oxytocin administration. It is concluded that oxytocin enhances uterine clearance of radiocolloid and may be useful for treating mares exhibiting impaired uterine clearance.
在13匹母马中测量了催产素对从子宫腔清除的99m锝白蛋白胶体（99mTc - microAA）百分比的影响。在连续4个发情周期进行闪烁扫描，在第1和第3周期的发情第3天以及第2和第4周期排卵后48小时进行。在第3和第4周期的初始闪烁扫描图像后静脉注射催产素（20国际单位）。7匹经产母马（第1组）被归类为对子宫内膜炎“敏感”，6匹母马（2匹初产和4匹经产；第2组）被归类为对子宫内膜炎“抵抗”。所有母马在注射催产素后30分钟内清除了> 90%的99mTc - microAA。当未给药时，第1组母马清除的放射性胶体量可忽略不计（< 5%），第2组母马清除50 - 80%。催产素给药后没有母马出现绞痛迹象。结论是催产素可增强子宫对放射性胶体的清除，可能有助于治疗子宫清除功能受损的母马。
