Yagi N, Takasu N, Higa S, Ishikawa K, Murakami K, Mimura G
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Horm Metab Res. 1995 Oct;27(10):439-41. doi: 10.1055/s-2007-979997.
Troglitazone, a newly developed oral antidiabetic agent, improves hyperglycemia, and has been reported to improve insulin resistance and to decrease hepatic glucose production in diabetic animals. However, the exact mechanism of Troglitazone on the improvement of insulin resistance is not known. Chronic administration of fructose to normal rats leads to hyperglycemia, and hyperinsulinemia; it induces insulin resistance. To reveal the mechanism of Troglitazone, we studied the effect of Troglitazone on serum glucose and insulin in the fructose-induced, insulin-resistant rats. Male Sprague-Dawley (SD) rats were fed either on standard chow or one containing fructose. Troglitazone was administrated as a food admixture (150 mg/kg/day) for 8 weeks. The rats were fed on (1) standard chow, (2) standard chow and Troglitazone, (3) fructose-enriched chow, or (4) fructose-enriched chow and Troglitazone. Blood samples were obtained every two weeks, and the levels of serum glucose and insulin were measured. Fructose-enriched chow increased serum glucose and insulin levels and insulin-to-glucose ratios. Troglitazone improved the fructose-induced increases in serum glucose, insulin levels, and insulin/glucose ratios. In conclusion, Troglitazone improved the fructose-induced insulin resistance.
曲格列酮是一种新开发的口服抗糖尿病药物，可改善高血糖，并且据报道在糖尿病动物中可改善胰岛素抵抗并降低肝脏葡萄糖生成。然而，曲格列酮改善胰岛素抵抗的确切机制尚不清楚。给正常大鼠长期喂食果糖会导致高血糖和高胰岛素血症，会诱导胰岛素抵抗。为了揭示曲格列酮的作用机制，我们研究了曲格列酮对果糖诱导的胰岛素抵抗大鼠血清葡萄糖和胰岛素的影响。雄性斯普拉格-道利（SD）大鼠分别喂食标准饲料或含果糖的饲料。曲格列酮作为食物添加剂（150毫克/千克/天）给药8周。大鼠分别喂食（1）标准饲料，（2）标准饲料和曲格列酮，（3）富含果糖的饲料，或（4）富含果糖的饲料和曲格列酮。每两周采集一次血样，并测量血清葡萄糖和胰岛素水平。富含果糖的饲料会提高血清葡萄糖、胰岛素水平以及胰岛素与葡萄糖的比率。曲格列酮改善了果糖诱导的血清葡萄糖、胰岛素水平及胰岛素/葡萄糖比率的升高。总之，曲格列酮改善了果糖诱导的胰岛素抵抗。
