Heatley M K
Department of Pathology, University of Sheffield, UK.
Histopathology. 1995 Nov;27(5):469-72. doi: 10.1111/j.1365-2559.1995.tb00312.x.
The aim of this study was to determine if the apoptotic index can be readily determined for endometrial carcinoma in hysterectomy specimens and to establish if any association exists between the apoptotic index and tumour grade and stage. The apoptotic index, defined as the percentage of morphologically identified apoptotic cells and apoptotic bodies in 3000 tumour cells, was calculated for 15 adenocarcinomas of the endometrium. An association between apoptotic index and tumour grade and stage was sought. Two grade 3 adenocarcinomas of endometrium had a higher apoptotic index (5.15% to 6.43%) than 13 grade 1 and 2 lesions (1.18% to 3.8%) and formed a distinct group in this series. No association between apoptotic index and tumour stage was demonstrable. Apoptotic index can be readily estimated in routine hysterectomy specimens for endometrial adenocarcinoma. A high apoptotic index shows an association with features normally correlated with a poor clinical outcome although its value as an independent prognostic index has yet to be established.
本研究的目的是确定是否能够在子宫切除标本中轻易测定子宫内膜癌的凋亡指数，并确定凋亡指数与肿瘤分级和分期之间是否存在关联。对15例子宫内膜腺癌计算凋亡指数，该指数定义为在3000个肿瘤细胞中形态学鉴定的凋亡细胞和凋亡小体的百分比。研究凋亡指数与肿瘤分级和分期之间的关联。2例3级子宫内膜腺癌的凋亡指数（5.15%至6.43%）高于13例1级和2级病变（1.18%至3.8%），在本系列中形成一个独特的组。未证明凋亡指数与肿瘤分期之间存在关联。在子宫内膜腺癌的常规子宫切除标本中可以轻易估计凋亡指数。高凋亡指数显示出与通常与不良临床结果相关的特征存在关联，尽管其作为独立预后指标的价值尚未确立。
