Taj R, Keenan E, O'Connor J J
Dept. of Psychiatry, Mater Hospital, Dublin.
Ir Med J. 1995 Nov-Dec;88(6):218-9.
This study involves a review of 178 patients on a strictly monitored methadone maintenance programme. All patients had a minimum of 9 years of intravenous drug misuse. 35.7% were HIV positive, 55.7% males and 29% females had previous prison sentences. On average patients had undergone 3.26 out-patient and 0.9 in-patient detoxification. 46.1% had attempted rehabilitation in the past. Out of 25,470 urine samples obtained while on the programme, 10.8% were positive for opiates, 19.2% for benzodiazepines, 32.5% for cannabis, 4.92% for alcohol and 2.27% for amphetamines. Long history of misuse, multiple custodial sentences, previous unsuccessful rehabilitation and positive HIV status were associated with acceptance for maintenance. Frequency of urinalysis, and results triggering dose change can effectively reduce illicit drug use.
本研究对178名接受严格监测的美沙酮维持治疗项目的患者进行了回顾。所有患者至少有9年静脉注射药物滥用史。35.7%为HIV阳性，55.7%为男性，29%的女性曾有过入狱经历。患者平均接受过3.26次门诊脱毒治疗和0.9次住院脱毒治疗。46.1%的患者过去曾尝试过康复治疗。在该项目期间采集的25470份尿液样本中，10.8%的样本鸦片类药物呈阳性，19.2%的样本苯二氮䓬类药物呈阳性，32.5%的样本大麻呈阳性，4.92%的样本酒精呈阳性，2.27%的样本苯丙胺呈阳性。滥用史长、多次被监禁、既往康复治疗未成功以及HIV阳性与接受维持治疗有关。尿液分析的频率以及触发剂量变化的结果可以有效减少非法药物的使用。
