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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Adv Exp Med Biol. 1977;76A:370-5. doi: 10.1007/978-1-4613-4223-6_47.

Incubation of normal and HGPRT-deficient fibroblasts with inosine results in increased PP-ribose-P concentrations. 2. The increased PP-ribose-P concentrations are accompanied by decreased rates of purine synthesis de novo, more marked in normal cells 3. Increased purine nucleotide concentrations during incubation with inosine provide a likely explanation for the inhibition of purine synthesis in normal cells 4. The lack of accelerated purine synthesis in mutant cells under these conditions is not fully explained by consideration of PP-ribose-P and purine nucleotide concentations.

正常成纤维细胞和次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）缺陷的成纤维细胞与肌苷一起孵育会导致磷酸核糖焦磷酸（PP - 核糖 - P）浓度升高。2. PP - 核糖 - P浓度升高伴随着嘌呤从头合成速率降低，在正常细胞中更明显。3. 与肌苷一起孵育期间嘌呤核苷酸浓度升高为正常细胞中嘌呤合成的抑制提供了一种可能的解释。4. 在这些条件下突变细胞中嘌呤合成缺乏加速，仅考虑PP - 核糖 - P和嘌呤核苷酸浓度并不能完全解释这一现象。

Adv Exp Med Biol. 1977;76A:370-5. doi: 10.1007/978-1-4613-4223-6_47.

Incubation of normal and HGPRT-deficient fibroblasts with inosine results in increased PP-ribose-P concentrations. 2. The increased PP-ribose-P concentrations are accompanied by decreased rates of purine synthesis de novo, more marked in normal cells 3. Increased purine nucleotide concentrations during incubation with inosine provide a likely explanation for the inhibition of purine synthesis in normal cells 4. The lack of accelerated purine synthesis in mutant cells under these conditions is not fully explained by consideration of PP-ribose-P and purine nucleotide concentations.

正常成纤维细胞和次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）缺陷的成纤维细胞与肌苷一起孵育会导致磷酸核糖焦磷酸（PP - 核糖 - P）浓度升高。2. PP - 核糖 - P浓度升高伴随着嘌呤从头合成速率降低，在正常细胞中更明显。3. 与肌苷一起孵育期间嘌呤核苷酸浓度升高为正常细胞中嘌呤合成的抑制提供了一种可能的解释。4. 在这些条件下突变细胞中嘌呤合成缺乏加速，仅考虑PP - 核糖 - P和嘌呤核苷酸浓度并不能完全解释这一现象。