Láhoda F, Athen D
Adv Exp Med Biol. 1977;76B:256-8. doi: 10.1007/978-1-4684-3285-5_37.
The increasing number of latent and manifest hyperuricemia is important concerning differential diagnosis in neurological and psychiatric diseases. The pathological importance of hyperuricemia in these diseases is particularly unknown. The possibility of a physiological regulative function of uric acid in central nervous system may be discussed. Therefore uric acid typing in cerebrospinal fluid were made of 173 patients with neurological and psychiatric diseases. On an average the uric acid level in cerebrospinal fluid is 1:10 of the blood uric acid level. In advanced age a lower level could be found. High level for example were found after L-Dopa treatment and epileptical seizures. These results and possible pathophysiological correlation to the correspondant diseases are discussed.
潜伏性和显性高尿酸血症病例数的增加，对于神经和精神疾病的鉴别诊断具有重要意义。高尿酸血症在这些疾病中的病理重要性尤其不明。可以探讨尿酸在中枢神经系统中具有生理调节功能的可能性。因此，对173例神经和精神疾病患者的脑脊液进行了尿酸分型。脑脊液中的尿酸水平平均为血尿酸水平的1/10。在老年患者中可发现较低水平。例如，在左旋多巴治疗和癫痫发作后发现尿酸水平较高。本文讨论了这些结果以及与相应疾病可能的病理生理相关性。
