Aghakhani N, Roux F X, Fallet-Bianco C, Devaux B
Service de Neurochirurgie, Hôpital Sainte-Anne, Paris.
Neurochirurgie. 1995;41(5):363-6.
Metastasis of intracranial glioblastomas have been described for the first time more than fifty years ago. They are exceptional and seem to develop clinically in less than 2% of cases. In fact, microscopic metastasis (necropsic series) of such glioblastomas are much more frequent: from 6% for supratentorial glioblastomas to 60% in infratentorial ones; but patients usually die before clinical symptoms appear. The authors report on an intraspinal metastasis which appeared clinically four years after the removal of a frontal glioblastoma. The metastasis was subdural, T3. Preoperative radiological data (CT-scan, MRI) evoked a meningioma, while surgical findings favoured the diagnosis of neurinoma. The diagnosis of glioblastoma metastasis was suggested by intra-operative pathological findings, and confirmed a few days later on smears and stains studies.
颅内胶质母细胞瘤的转移在五十多年前首次被描述。它们很罕见,临床上似乎不到2%的病例会出现。事实上,这类胶质母细胞瘤的微观转移(尸检系列)更为常见:幕上胶质母细胞瘤为6%,幕下胶质母细胞瘤为60%;但患者通常在临床症状出现前就死亡了。作者报告了一例在额叶胶质母细胞瘤切除四年后临床上出现的脊髓内转移。转移灶位于硬脑膜下,T3水平。术前影像学资料(CT扫描、MRI)提示为脑膜瘤,而手术所见更倾向于神经鞘瘤的诊断。术中病理发现提示为胶质母细胞瘤转移,并在几天后的涂片和染色研究中得到证实。