O'Mara S M, Rowan M J, Anwyl R
Department of Physiology, Trinity College, Dublin, Republic of Ireland.
Neuroscience. 1995 Oct;68(3):621-4. doi: 10.1016/0306-4522(95)00233-9.
The involvement of Ca release from intracellular stores in the induction of long-term depression and depotentiation of excitatory synaptic transmission was investigated in the rat dentate gyrus using dantrolene, an agent known to block Ca release via the ryanodine receptor. In control slices, low-frequency stimulation (1 Hz for 15 min) induced robust long-term depression of baseline field excitatory postsynaptic potentials and depotentiation of previously established long-term potentiation. Dantrolene (50 microM) was found to block completely both long-term depression of baseline responses and depotentiation. Moreover, long-term potentiation induced by high-frequency stimulation was enhanced in the presence of dantrolene.
利用丹曲林（一种已知可通过雷诺丁受体阻断钙释放的药物），在大鼠齿状回中研究了细胞内钙库释放钙在诱导长时程抑制和兴奋性突触传递去增强中的作用。在对照切片中，低频刺激（1赫兹，持续15分钟）可诱导基线场兴奋性突触后电位出现强烈的长时程抑制以及对先前建立的长时程增强的去增强。发现丹曲林（50微摩尔）可完全阻断基线反应的长时程抑制和去增强。此外，在丹曲林存在的情况下，高频刺激诱导的长时程增强增强。
