帕金森病患者中P物质和甲硫氨酸脑啡肽在基因中的纹状体表达。

Striatal expression of substance P and methionin-enkephalin in genes in patients with Parkinson's disease.

作者信息

Levy R, Vila M, Herrero M T, Faucheux B, Agid Y, Hirsch E C

机构信息

INSERM U289, Hôpital de la Salpêtrière, Paris, France.

出版信息

Neurosci Lett. 1995 Oct 27;199(3):220-4. doi: 10.1016/0304-3940(95)12011-r.

DOI:10.1016/0304-3940(95)12011-r

PMID:8577402

Abstract

The striatal expression of substance P (SP) and methionin-enkephalin (met-enk) genes was studied post mortem by in situ hybridization in patients with Parkinson's disease and a group of control subjects. No significant difference in striatal expression of these two neuropeptide messenger RNAs (mRNAs) was found in the patients compared with control subjects. This contrasts with animal models of parkinsonism, where expression of SP mRNA is decreased and met-enk mRNA increased. Possible explanations include: (1) compensatory mechanisms, which may develop during the long term evolution of Parkinson's disease; (2) normalized expression of the two genes resulting from chronic L-DOPA therapy.

摘要

通过对帕金森病患者及一组对照受试者进行死后原位杂交，研究了P物质（SP）和甲硫氨酸脑啡肽（met-enk）基因在纹状体中的表达。与对照受试者相比，在患者中未发现这两种神经肽信使核糖核酸（mRNA）在纹状体中的表达有显著差异。这与帕金森病动物模型形成对比，在帕金森病动物模型中，SP mRNA表达降低而met-enk mRNA表达增加。可能的解释包括：（1）补偿机制，这可能在帕金森病的长期演变过程中形成；（2）长期左旋多巴治疗导致这两个基因的表达正常化。