ISIS 4：关于静脉输注镁、溶栓治疗与急性心肌梗死的临床争议

ISIS 4: clinical controversy regarding magnesium infusion, thrombolytic therapy, and acute myocardial infarction.

作者信息

Seelig M S

机构信息

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, USA.

出版信息

Nutr Rev. 1995 Sep;53(9):261-4. doi: 10.1111/j.1753-4887.1995.tb05483.x.

DOI:10.1111/j.1753-4887.1995.tb05483.x

PMID:8577409

Abstract

Magnesium (Mg) infusions over 24 hours were given to patients with suspected acute myocardial infarction (AMI) at least 2 hours after thrombolysis. Patients showed no benefit and even some increased risk in contrast to reduction in mortality obtained by Mg therapy in smaller trials. Results of all of the studies were pooled and statistically analyzed, according to a fixed-effects model that is inappropriate for studies of different protocols. The panel concluded that further study of Mg in AMI is not needed. This conclusion has been questioned.

摘要

在溶栓治疗至少2小时后，对疑似急性心肌梗死（AMI）患者进行了24小时的镁（Mg）输注。与小型试验中镁治疗降低死亡率相反，这些患者未显示出益处，甚至风险有所增加。根据不适用于不同方案研究的固定效应模型，汇总并统计分析了所有研究的结果。该小组得出结论，不需要对急性心肌梗死中的镁进行进一步研究。这一结论受到了质疑。