乙肝表面抗原健康携带者的微粒体功能：通过¹⁴C-咖啡因呼气试验评估细胞色素P450 1A2活性

Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.

作者信息

Horsmans Y, De Koninck X, Geubel A P, Pauwels S

机构信息

Department of Gastroenterology, St. Luc University Hospital (UCL), Bruxelles, Belgium.

出版信息

Pharmacol Toxicol. 1995 Oct;77(4):247-9. doi: 10.1111/j.1600-0773.1995.tb01021.x.

DOI:10.1111/j.1600-0773.1995.tb01021.x

PMID:8577634

Abstract

The hepatitis B surface antigen (HBsAg) carrier state is associated with changes in hepatocellular function involving the cytochrome P450 (CYP) system. Among this system, CYP1A2 enzyme plays an important role in chemical carcinogenesis and in the metabolism of several drugs. We have thus investigated CYP1A2 function using two 14C-caffeine breath tests (3-methyl-14C; C3BT and 7-methyl-14C caffeine; C7BT) in 12 HBsAg healthy carriers and 8 healthy volunteers matched for 14C-aminopyrine breath test values. HBsAg carriers exhibited lower C3- and C7BT values than normal controls. This difference, however, did not reach statistical significance except for C7BT values normalised for aminopyrine breath test values. Our data thus do not support the association between viral presence and CYP1A2 dysfunction.

摘要

乙肝表面抗原（HBsAg）携带状态与涉及细胞色素P450（CYP）系统的肝细胞功能变化有关。在该系统中，CYP1A2酶在化学致癌作用及多种药物的代谢过程中发挥重要作用。因此，我们采用两项14C-咖啡因呼气试验（3-甲基-14C；C3BT和7-甲基-14C咖啡因；C7BT），对12名HBsAg健康携带者和8名14C-氨基比林呼气试验值相匹配的健康志愿者的CYP1A2功能进行了研究。HBsAg携带者的C3BT和C7BT值低于正常对照组。然而，除了经氨基比林呼气试验值标准化后的C7BT值外，这种差异未达到统计学意义。因此，我们的数据不支持病毒存在与CYP1A2功能障碍之间的关联。