Chory J, Cook R K, Dixon R, Elich T, Li H M, Lopez E, Mochizuki N, Nagpal P, Pepper A, Poole D
Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Philos Trans R Soc Lond B Biol Sci. 1995 Oct 30;350(1331):59-65. doi: 10.1098/rstb.1995.0138.
All metazoan cells are able to make decisions about cell division or cellular differentiation based, in part, on environmental cues. Accordingly, cells express receptor systems that allow them to detect the presence of hormones, growth factors and other signals that manipulate the regulatory processes of the cell. In plants, an unusual signal-light-is required for the induction and regulation of many developmental processes. Past physiological and molecular studies have revealed the variety and complexity of plant responses to light but until recently very little was known about the mechanisms of those responses. Two major breakthroughs have allowed the identification of some photoreceptor signalling intermediates: the identification of photoreceptor and signal transduction mutants in Arabidopsis, and the development of single-cell microinjection assays in which outcomes of photoreceptor signalling can be visualized. Here, we review recent genetic advances which support the notion that light responses are not simply endpoints of linear signal transduction pathways, but are the result of the integration of a variety of input signals through a complex network of interacting signalling components.
所有后生动物细胞都能够部分基于环境线索对细胞分裂或细胞分化做出决策。因此，细胞表达受体系统，使其能够检测激素、生长因子和其他操纵细胞调节过程的信号的存在。在植物中，许多发育过程的诱导和调节需要一种特殊的信号——光。过去的生理学和分子研究揭示了植物对光反应的多样性和复杂性，但直到最近，人们对这些反应的机制知之甚少。两项重大突破使得一些光受体信号转导中间体得以鉴定：拟南芥中光受体和信号转导突变体的鉴定，以及单细胞显微注射分析方法的发展，通过该方法可以观察到光受体信号转导的结果。在这里，我们回顾了最近的遗传学进展，这些进展支持了这样一种观点，即光反应不仅仅是线性信号转导途径的终点，而是通过复杂的相互作用信号成分网络整合各种输入信号的结果。
