Roman G, Ecker J R
Department of Biology, University of Pennsylvania, Philadelphia 19104-6018, USA.
Philos Trans R Soc Lond B Biol Sci. 1995 Oct 30;350(1331):75-81. doi: 10.1098/rstb.1995.0140.
A genetic framework has been devised for the action of genes within the ethylene-response pathway. This working model is based on the epistatic interactions among a variety of ethylene response mutations. Most of the mutations that have been described act in a linear pathway. Genes controlling cell elongation in response to ethylene must, at some level, act to affect the architecture of the cytoskeleton. Genes that act late in the pathway, in mutant form, may lead to highly specific phenotypes such as the increased sensitivity to taxol in the ein6 mutant. Analysis of these downstream components may provide critical insights into the nature of ethylene's effect on the cell elongation machinery.
已经设计了一个关于乙烯反应途径中基因作用的遗传框架。这个工作模型基于多种乙烯反应突变之间的上位性相互作用。大多数已描述的突变以线性途径起作用。响应乙烯控制细胞伸长的基因，在某种程度上，必定作用于影响细胞骨架的结构。在该途径后期起作用的基因，以突变形式存在时，可能导致高度特异性的表型，如ein6突变体对紫杉醇的敏感性增加。对这些下游组分的分析可能为乙烯对细胞伸长机制影响的本质提供关键见解。
