Couroucé A M, Barin F, Botté C, Lunel F, Maisonneuve P, Maniez M, Trepo C
Institut National de Transfusion Sanguine, Paris, France.
Vox Sang. 1995;69(3):213-6. doi: 10.1111/j.1423-0410.1995.tb02597.x.
The sensitivity of the most recent generation of anti-hepatitis C virus (anti-HCV) screening tests from seven manufacturers was evaluated with a common panel of 530 specimens from 320 HCV-infected subjects. This panel included 221 samples from 57 seroconverters (53 pre-sero conversion negative specimens and 168 positive samples) and 309 selected specimens from 263 other HCV-infected patients of which 19% exhibited NS3 or core reactivity alone with the presence of HCV-RNA assessed by PCR. None of the seven screening tests detected all infectious and antibody-positive specimens. However, important differences were observed between these assays in the number of false-negative results, which seemed mainly due to nonreactivity of antibody to the NS3 antigen.
使用来自320名丙型肝炎病毒（HCV）感染受试者的530份样本组成的通用样本组，对7家制造商生产的最新一代抗HCV筛查试验的敏感性进行了评估。该样本组包括来自57名血清转化者的221份样本（53份血清转化前阴性样本和168份阳性样本），以及从263名其他HCV感染患者中选取的309份样本，其中19%的样本仅表现出NS3或核心反应性，通过PCR评估存在HCV-RNA。7种筛查试验均未检测出所有感染性和抗体阳性样本。然而，这些检测在假阴性结果数量上存在重要差异，这似乎主要是由于抗体对NS3抗原无反应性所致。
