Hoenich N A, Appleton D, Cox P J, Woffindin C
Department of Medicine, Medical School University of Newcastle upon Tyne, U.K.
Artif Organs. 1995 Nov;19(11):1136-42. doi: 10.1111/j.1525-1594.1995.tb02275.x.
The effectiveness of solute removal of a hemodialyzer may be judged by the ability of the device to remove solutes over the clinical range of blood flow rates. The expression of solute removal characteristics of hemodialyzers at standard or specific blood flow rates is important for clinical use and comparison. The solute removal at a specific blood flow rate is derived mathematically, usually by the fitting of a curve to the blood flow solute removal characteristics established experimentally over a range of blood flow rates. The commonly used methods of obtaining such a relationship are discussed and a new method of curve fitting is described. This method is derived from the mathematical theory defining the overall dialyzer mass transport relationship which governs the clearance blood flow relationship in any dialyzer. The derived relationship between the blood flow rate and the clearance has been validated using data generated for a commercially produced hemodialyzer.
血液透析器溶质清除的有效性可通过该设备在临床血流速率范围内清除溶质的能力来判断。在标准或特定血流速率下表达血液透析器的溶质清除特性对于临床应用和比较很重要。特定血流速率下的溶质清除是通过数学推导得出的，通常是通过将曲线拟合到在一系列血流速率上通过实验建立的血流溶质清除特性。文中讨论了获得这种关系的常用方法，并描述了一种新的曲线拟合方法。该方法源自定义整个透析器质量传输关系的数学理论，该理论支配任何透析器中的清除率与血流关系。使用为一种商业生产的血液透析器生成的数据验证了推导得出的血流速率与清除率之间的关系。
