与使用大鼠模型的骨骼研究中的生物力学研究相关的外周定量计算机断层扫描（pQCT）技术的前景。

Perspectives of pQCT technology associated to biomechanical studies in skeletal research employing rat models.

作者信息

Ferretti J L

机构信息

CEMFoC-CIUNR-CONICET, National University of Rosario, Argentina.

出版信息

Bone. 1995 Oct;17(4 Suppl):353S-364S. doi: 10.1016/8756-3282(95)00313-3.

DOI:10.1016/8756-3282(95)00313-3

PMID:8579938

Abstract

Assessment of bone material quality and architectural indicators by means of peripheral quantitative computed tomography (pQCT) offers a wide perspective for skeletal research employing noninvasive procedures. Some mechanically-validated examples of these pQCT applications in animal models are described. They concern (a) the analysis of bone mechanostatical interrelationships as shown by experimental "distribution/quality" curves, and (b) the noninvasive determination of bone strength. An attractive attempt to extrapolate the latter to human bone studies is also discussed.

摘要

通过外周定量计算机断层扫描（pQCT）评估骨材料质量和结构指标，为采用非侵入性程序的骨骼研究提供了广阔的前景。本文描述了这些pQCT在动物模型中的一些经过力学验证的应用实例。它们涉及（a）通过实验“分布/质量”曲线所示的骨机械稳态相互关系分析，以及（b）骨强度的非侵入性测定。还讨论了将后者外推至人体骨骼研究的一项有吸引力的尝试。