Berlin I, Said S, Spreux-Varoquaux O, Olivares R, Launay J M, Puech A J
Department of Clinical Pharmacology, Hôpital Pitié-Salpêtrière, Paris, France.
Biol Psychiatry. 1995 Dec 1;38(11):756-61. doi: 10.1016/0006-3223(95)00084-4.
There is a strong association between depression and smoking. Because monoamine oxidase (MAO) inhibition leads to antidepressant effect and in vitro studies have shown that cigarette smoke inhibits MAO activity, it is conceivable that smoking may have an antidepressant effect, if smokers have reduced MAO activity. Therefore, we assessed platelet MAO-B activity and plasma concentration of catecholamine metabolites reflecting MAO-A activity in heavy dependent smokers and nonsmokers matched for sociodemographic characteristics. Platelet MAO-B activity, plasma 3,4-dihydroxyphenylglycol, plasma 3,4-dihydroxyphenylacetic acid, and plasma 3,4-dihydroxyphenylalanine concentrations were significantly lower in smokers than in nonsmokers, whereas plasma norepinephrine did not differ. Significantly more smokers reported previous history of depression, manic episode, panic attack, agoraphobia, and simple phobia. Smokers had higher scores (p < 0.001) on the Montgomery-Asberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Scales. It is concluded that the activities of both forms of the MAO are reduced in heavy dependent smokers.
抑郁症与吸烟之间存在密切关联。由于单胺氧化酶（MAO）抑制会产生抗抑郁作用，且体外研究表明香烟烟雾会抑制MAO活性，因此可以推测，如果吸烟者的MAO活性降低，吸烟可能具有抗抑郁作用。因此，我们评估了重度依赖吸烟者和社会人口学特征相匹配的非吸烟者的血小板MAO - B活性以及反映MAO - A活性的儿茶酚胺代谢物的血浆浓度。吸烟者的血小板MAO - B活性、血浆3,4 - 二羟基苯乙二醇、血浆3,4 - 二羟基苯乙酸和血浆3,4 - 二羟基苯丙氨酸浓度显著低于非吸烟者，而血浆去甲肾上腺素无差异。显著更多的吸烟者报告有抑郁症、躁狂发作、惊恐发作、广场恐惧症和单纯恐惧症的既往史。吸烟者在蒙哥马利 - 阿斯伯格抑郁评定量表（MADRS）和汉密尔顿焦虑量表上的得分更高（p < 0.001）。研究得出结论，重度依赖吸烟者两种形式的MAO活性均降低。
