Norman T R, Chamberlain K G, French M A, Burrows G D
J Affect Disord. 1982 Mar;4(1):73-7. doi: 10.1016/0165-0327(82)90021-0.
Platelet MAO activity and plasma thiocyanate concentrations were determined in 72 normal volunteers (22 non-smokers and 50 smokers). Thiocyanate concentrations were used as an index of exposure to cigarette smoke. A significant negative correlation between MAO and thiocyanate concentration was observed for the group (rs = 0.35; P less than 0.005). When examined by sex, the correlation was significant for females but not for males. Mean MAO activity was significantly lower for female smokers than for female non-smokers. For males, no significant differences in MAO activity were observed between smokers and non-smokers. It is possible that smoking causes inhibition of MAO by a direct effect or by indirect effects such as altering hormone levels. Alternatively women with a low MAO activity have a greater innate tendency to smoke.
对72名正常志愿者（22名不吸烟者和50名吸烟者）测定了血小板单胺氧化酶（MAO）活性和血浆硫氰酸盐浓度。硫氰酸盐浓度被用作接触香烟烟雾的指标。该组中观察到MAO与硫氰酸盐浓度之间存在显著负相关（rs = 0.35；P < 0.005）。按性别检查时，女性的相关性显著，而男性则不显著。女性吸烟者的平均MAO活性显著低于女性不吸烟者。对于男性，吸烟者和不吸烟者之间未观察到MAO活性的显著差异。吸烟可能通过直接作用或通过改变激素水平等间接作用导致MAO受到抑制。或者，MAO活性低的女性有更大的先天吸烟倾向。
