Bonner D, Howard R
Maudsley Hospital, London, England, UK.
Int Psychogeriatr. 1995;7 Suppl:83-94. doi: 10.1017/s1041610295002377.
Apparent treatment-resistant depression (TRD) is frequently encountered by and poses particular challenges for the old-age psychiatrist. The prevalence of true nonresponse to treatment is not known with accuracy but reports put it at 18% to 40% for the elderly. This article reviews the concept of TRD in the elderly, discussing the factors involved in apparent resistance and the treatment of this group. We suggest that absolute TRD may be a rarer entity than the estimated 18% to 40% if depressed patients are treated carefully and vigorously.
老年精神科医生经常会遇到明显的难治性抑郁症（TRD），这给他们带来了特殊的挑战。对治疗真正无反应的患病率尚无法准确得知，但报告显示老年人的这一比例为18%至40%。本文回顾了老年人TRD的概念，讨论了明显耐药的相关因素以及该群体的治疗方法。我们认为，如果对抑郁症患者进行仔细且积极的治疗，绝对的TRD可能比估计的18%至40%更为罕见。
