Richard O, Hevor T
Laboratoire de Physiologie, Jeune Equipe n. 268, Université d'Orléans, France.
Neuroreport. 1995 Oct 23;6(15):2027-32. doi: 10.1097/00001756-199510010-00018.
Methionine sulfoximine induces epileptiform convulsions in rats. A possible involvement of acetylcholine in the onset of convulsions was investigated. A subconvulsive dose of methionine sulfoximine increased the brain acetylcholine concentration. After administration of a convulsive dose, atropine neither prevented the onset of the seizures nor prevented the increase in acetylcholine concentration. Physostigmine enhanced the increase in acetylcholine level but did not modify the time course nor the intensity of the convulsions. L-DOPA suppressed the seizures without inhibiting the increase in acetylcholine level. The choline content decreased after the convulsant dose. The increase in acetylcholine content is therefore not the unique cause of the seizures, which could result from the reduction of striatal inhibition due to a decrease in dopamine level induced by methionine sulfoximine.
蛋氨酸亚砜亚胺可诱发大鼠癫痫样惊厥。研究了乙酰胆碱在惊厥发作中可能的作用。亚惊厥剂量的蛋氨酸亚砜亚胺可提高脑内乙酰胆碱浓度。给予惊厥剂量后，阿托品既不能预防癫痫发作，也不能阻止乙酰胆碱浓度的升高。毒扁豆碱增强了乙酰胆碱水平的升高，但未改变惊厥的时间进程和强度。左旋多巴可抑制惊厥发作，而不抑制乙酰胆碱水平的升高。惊厥剂量给药后胆碱含量降低。因此，乙酰胆碱含量的增加并非惊厥的唯一原因，惊厥可能是由于蛋氨酸亚砜亚胺诱导多巴胺水平降低导致纹状体抑制作用减弱所致。
