Fendt M, Koch M, Kungel M, Schnitzler H U
Universität Tübingen, Germany.
Neuroreport. 1995 Oct 23;6(15):2081-4. doi: 10.1097/00001756-199510010-00030.
The present study examined the effects of the neuropeptide cholecystokinin (CCK) on neurones of the caudal pontine reticular nucleus (PnC), which mediates the acoustic startle response (ASR) in rats. Electrophysiological experiments revealed an excitatory effect of CCK on acoustically responsive neurones in the PnC. On the behavioural level, CCK also enhanced the ASR. Since the PnC is not only an obligatory relay station of the brain circuit mediating the ASR, but also receives modulatory input from brain areas involved in the expression of fear and anxiety, the enhancement of the ASR by CCK could be interpreted as an anxiogenic-like effect of this peptide.
本研究检测了神经肽缩胆囊素（CCK）对大鼠脑桥尾侧网状核（PnC）神经元的影响，该核团介导大鼠的听觉惊吓反应（ASR）。电生理实验揭示了CCK对PnC中听觉反应神经元的兴奋作用。在行为水平上，CCK也增强了ASR。由于PnC不仅是介导ASR的脑回路的一个必要中继站，还接受来自参与恐惧和焦虑表达的脑区的调节性输入，因此CCK对ASR的增强作用可被解释为该肽的类焦虑效应。
