非胰岛素依赖型糖尿病合并特发性甲状旁腺功能减退症。

Non-insulin-dependent diabetes mellitus complicated with idiopathic hypoparathyroidism.

作者信息

Itoh H, Matsuda Y, Nishiyama M, Kitagawa T, Kobayashi T, Nio Y, Hama S, Hosogi H, Hiroi T, Hashimoto K

机构信息

Department of Internal Medicine, Hosogi Hospital, Kochi.

出版信息

Intern Med. 1995 Sep;34(9):904-7. doi: 10.2169/internalmedicine.34.904.

DOI:10.2169/internalmedicine.34.904

PMID:8580567

Abstract

We report a case of non-insulin-dependent diabetes mellitus (NIDDM) complicated with idiopathic hypoparathyroidism. A 74-year-old male was hospitalized because of diplopia. He was revealed to have NIDDM. The levels of serum Ca and intact-PTH were 6.3 mg/dl and < 5 pg/ml, respectively. Brain computed tomography revealed abnormal calcification in the cerebral basal ganglia and the cerebellum. After recovery from hypocalcemia, the endogenous insulin secretion was normalized. It is suggested that the pathogenesis of NIDDM in this patient may have been related to an insulin secretory defect as a result of hypocalcemia in addition to the hereditary risk.

摘要

我们报告一例非胰岛素依赖型糖尿病（NIDDM）合并特发性甲状旁腺功能减退症的病例。一名74岁男性因复视而住院。他被诊断为NIDDM。血清钙和完整甲状旁腺激素水平分别为6.3mg/dl和<5pg/ml。脑部计算机断层扫描显示大脑基底节和小脑有异常钙化。低钙血症恢复后，内源性胰岛素分泌恢复正常。提示该患者NIDDM的发病机制除遗传风险外，可能还与低钙血症导致的胰岛素分泌缺陷有关。