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肺癌垂体转移导致的中枢性尿崩症。

Central diabetes insipidus caused by pituitary metastasis of lung cancer.

作者信息

Matsuda R, Chiba E, Kawana I, Kihara M, Tomiyama M, Ebira H, Ikegami T, Kitamura H

机构信息

Second Department of Internal Medicine, Yokohama Minami Kyosai Hospital.

出版信息

Intern Med. 1995 Sep;34(9):913-8. doi: 10.2169/internalmedicine.34.913.

DOI:10.2169/internalmedicine.34.913
PMID:8580569
Abstract

Tumor metastasis to the hypophyseal system has rarely been reported with either clinical or radiographic evidence. A 52-year-old woman presented with polydipsia, polyuria, and loss of appetite. She was diagnosed as having diabetes insipidus caused by pituitary micrometatasis of lung adenocarcinoma. After she had been treated with radiation therapy to the pituitary gland, the gland size was reduced as confirmed by magnetic resonance imaging, and her urine volume decreased. However, meningitis carcinomatosa appeared later. This was a rare case of secondary diabetes insipidus due to pituitary metastasis of lung cancer.

摘要

肿瘤转移至垂体系统的临床或影像学证据鲜有报道。一名52岁女性出现烦渴、多尿和食欲减退症状。她被诊断为因肺腺癌垂体微转移导致的尿崩症。在接受垂体放疗后,磁共振成像证实垂体大小缩小,尿量减少。然而,随后出现了癌性脑膜炎。这是一例因肺癌垂体转移导致继发性尿崩症的罕见病例。

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Central diabetes insipidus caused by pituitary metastasis of lung cancer.肺癌垂体转移导致的中枢性尿崩症。
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Panhypopituitarism caused by solitary parasellar metastasis from lung cancer.肺癌鞍旁孤立转移瘤所致的全垂体功能减退症
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Diabetes insipidus caused by pituitary gland metastasis accompanied by iris metastasis of small cell lung cancer: case presentation and review of the literature.垂体转移瘤伴小细胞肺癌虹膜转移所致尿崩症:病例报告及文献复习
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Pituitary metastasis: lung cancer presenting as bitemporal hemianopsia with diabetes insipidus and anterior pituitary deficiency.垂体转移瘤:以双颞侧偏盲、尿崩症和垂体前叶功能减退为表现的肺癌。
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引用本文的文献

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Diabetes insipidus as a presentation of lung adenocarcinoma: a case report.尿崩症作为肺腺癌的一种表现:一例病例报告。
J Med Case Rep. 2025 Aug 13;19(1):403. doi: 10.1186/s13256-025-05420-x.
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Severe Hyponatremia Masking Central Diabetes Insipidus in a Patient with a Lung Adenocarcinoma.严重低钠血症掩盖肺腺癌患者中枢性尿崩症
Case Rep Oncol. 2022 Feb 9;15(1):91-98. doi: 10.1159/000521608. eCollection 2022 Jan-Apr.
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Gefitinib Treatment Was Unsuccessful for Central Diabetes Insipidus Due to Pituitary Metastasis of Lung Adenocarcinoma.
吉非替尼治疗肺腺癌垂体转移所致中枢性尿崩症失败。
Intern Med. 2021 Apr 1;60(7):1073-1076. doi: 10.2169/internalmedicine.5643-20. Epub 2020 Nov 9.
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Diabetes insipidus and panhypopituitarism as a first presentation of silent adenocarcinoma of lung: a case report and literature review.尿崩症和全垂体功能减退作为肺静默腺癌的首发表现:一例病例报告并文献复习。
BMC Endocr Disord. 2019 Oct 29;19(1):114. doi: 10.1186/s12902-019-0445-5.
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Pituitary metastasis: a rare condition.垂体转移瘤:一种罕见病症。
Endocr Connect. 2018 Aug 23;7(10):1049-57. doi: 10.1530/EC-18-0338.
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Clinical and biochemical characteristic features of metastatic cancer to the sella turcica: an analytical review.鞍区转移癌的临床和生化特征:分析综述。
Pituitary. 2014 Dec;17(6):575-87. doi: 10.1007/s11102-013-0542-9.