Carraway K L, Burden S J
Harvard Medical School, Boston, USA.
Curr Opin Neurobiol. 1995 Oct;5(5):606-12. doi: 10.1016/0959-4388(95)80065-4.
The recent identification of an activator for the ErbB2/Neu receptor has uncovered a new family of polypeptide growth factors that undoubtedly play a major role in the regulation of neuronal growth and differentiation. These factors, called the neuregulins, are expressed in neural and mesenchymal tissues, and activate members of the epidermal growth factor family of receptor tyrosine kinases. The identification and characterization of the neuregulins and their receptors will facilitate the dissection of the biochemical pathways regulating nervous system development.
最近对ErbB2/Neu受体激活剂的鉴定，揭示了一个新的多肽生长因子家族，它们无疑在神经元生长和分化的调节中发挥着重要作用。这些因子被称为神经调节蛋白，在神经组织和间充质组织中表达，并激活受体酪氨酸激酶的表皮生长因子家族成员。神经调节蛋白及其受体的鉴定和表征将有助于剖析调节神经系统发育的生化途径。
