Doyle J J, Thorner P, Poon A, Tanswell K, Kamel-Reid S, Zipursky A
Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Leuk Lymphoma. 1995 Apr;17(3-4):345-50. doi: 10.3109/10428199509056843.
A case is presented of a child with mosaic Down syndrome, who presented at birth with a transient leukemia and later progressed to megakaryoblastic leukemia. Evidence is presented that both leukemias were of megakaryoblastic lineage and evolved from a trisomic hematopoietic precursor. This case is unique in the poor course of the initial transient neonatal leukemia with improvement following chemotherapy. It also highlights the form of leukemia and associated myelodysplasia that occurs in children with Down syndrome. This form of leukemia and transient leukemia are interrelated and are unique to children with Down syndrome.
本文报告了一例患有嵌合型唐氏综合征的儿童病例，该患儿出生时患有短暂性白血病，随后进展为巨核细胞白血病。有证据表明，这两种白血病均为巨核细胞系，且由三体造血前体细胞演变而来。该病例的独特之处在于，初始短暂性新生儿白血病病程不佳，但化疗后有所改善。它还突出了唐氏综合征患儿中出现的白血病形式及相关骨髓发育异常。这种白血病形式与短暂性白血病相互关联，是唐氏综合征患儿所特有的。
