利用侧链芳烃对铵阳离子进行蛋白质识别：仲铵配体的结构变异
Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands.
作者信息
Raine A R, Yang C C, Packman L C, White S A, Mathews F S, Scrutton N S
机构信息
Department of Biochemistry, University of Cambridge, United Kingdom.
出版信息
Protein Sci. 1995 Dec;4(12):2625-8. doi: 10.1002/pro.5560041222.
Abstract
A model for the structure of dimethylamine dehydrogenase was generated using the crystal coordinates of trimethylamine dehydrogenase. Substrate is bound in trimethylamine dehydrogenase by cation-pi bonding, but modeling of dimethylamine dehydrogenase suggests that secondary amines are bound by a mixture of cation-pi and conventional hydrogen bonding. In dimethylamine dehydrogenase, binding is orientationally more specific and distinct from those proteins that bind tertiary and quaternary amine groups.
摘要
利用三甲胺脱氢酶的晶体坐标生成了二甲胺脱氢酶的结构模型。底物在三甲胺脱氢酶中通过阳离子-π键结合，但二甲胺脱氢酶的模型表明仲胺是通过阳离子-π键和传统氢键的混合方式结合的。在二甲胺脱氢酶中，结合在方向上更具特异性，且与那些结合叔胺和季胺基团的蛋白质不同。
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本文引用的文献
1
The reaction of trimethylamine dehydrogenase with diethylmethylamine.三甲胺脱氢酶与二乙甲基胺的反应。
J Biol Chem. 1994 Dec 9;269(49):30869-79.
2
Electron tunneling in substrate-reduced trimethylamine dehydrogenase: kinetics of electron transfer and analysis of the tunneling pathway.
Biochemistry. 1995 Feb 28;34(8):2584-91. doi: 10.1021/bi00008a024.
3
On the evolution of alternate core packing in eightfold beta/alpha-barrels.关于八重β/α桶状结构中交替核心堆积的演变
Protein Sci. 1994 Oct;3(10):1889-92. doi: 10.1002/pro.5560031028.
4
Structural basis of antibody function.抗体功能的结构基础。
Annu Rev Immunol. 1983;1:87-117. doi: 10.1146/annurev.iy.01.040183.000511.
5
Hydrogen bonding in globular proteins.球状蛋白质中的氢键。
Prog Biophys Mol Biol. 1984;44(2):97-179. doi: 10.1016/0079-6107(84)90007-5.
6
Three-dimensional structure of the iron-sulfur flavoprotein trimethylamine dehydrogenase at 2.4-A resolution.
J Biol Chem. 1986 Nov 15;261(32):15140-6.
7
Amino-aromatic interactions in proteins.蛋白质中的氨基-芳香族相互作用。
FEBS Lett. 1986 Jul 28;203(2):139-43. doi: 10.1016/0014-5793(86)80730-x.
8
Studies of crystalline trimethylamine dehydrogenase in three oxidation states and in the presence of substrate and inhibitor.
J Biol Chem. 1989 Jul 15;264(20):11887-92.
9
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.加州电鳐乙酰胆碱酯酶的原子结构：一种典型的乙酰胆碱结合蛋白。
Science. 1991 Aug 23;253(5022):872-9. doi: 10.1126/science.1678899.
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