伤寒沙门氏菌不会抑制人单核细胞衍生巨噬细胞中的吞噬体-溶酶体融合。
Salmonella typhi does not inhibit phagosome-lysosome fusion in human monocyte-derived macrophages.
作者信息
Ishibashi Y, Arai T
机构信息
Department of Microbiology, Meiji College of Pharmacy, Tokyo, Japan.
出版信息
FEMS Immunol Med Microbiol. 1995 Sep;12(1):55-61. doi: 10.1111/j.1574-695X.1995.tb00175.x.
We examined phagosome-lysosome fusion in Salmonella typhi-infected human monocyte-derived macrophages and its relevance to the intracellular survival of this bacterium in vitro. S. typhi was found to survive and multiply in human monocyte-derived macrophages, whereas S. typhimurium was killed easily, indicating that the survival of Salmonella serovars is host-specific. Neither S. typhi nor S. typhimurium inhibited phagosome-lysosome fusion in human monocyte-derived macrophages. No difference between the phagosome-lysosome fusibilities of freshly prepared human monocytes and monocyte-derived macrophages was observed. These results suggest that S. typhi may survive by adapting to the conditions within fused phagolysosomes of human monocyte-derived macrophages.
我们研究了伤寒沙门氏菌感染的人单核细胞衍生巨噬细胞中的吞噬体-溶酶体融合及其与该细菌在体外细胞内存活的相关性。发现伤寒沙门氏菌能在人单核细胞衍生巨噬细胞中存活并繁殖，而鼠伤寒沙门氏菌则很容易被杀死，这表明沙门氏菌血清型的存活具有宿主特异性。伤寒沙门氏菌和鼠伤寒沙门氏菌均未抑制人单核细胞衍生巨噬细胞中的吞噬体-溶酶体融合。未观察到新鲜制备的人单核细胞和单核细胞衍生巨噬细胞在吞噬体-溶酶体融合能力上的差异。这些结果表明，伤寒沙门氏菌可能通过适应人单核细胞衍生巨噬细胞融合吞噬溶酶体内的条件而存活。
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