Peehl D M, Rubin J S
Department of Urology, Stanford University School of Medicine, CA 94305-5118, USA.
World J Urol. 1995;13(5):312-7. doi: 10.1007/BF00185975.
Members of the fibroblast growth factor (FGF) family are important growth-regulatory elements. Of the FGFs, keratinocyte growth factor (KGF) appears to have unique properties that implicate it as a paracrine factor in the prostate. Two KGF transcripts (approximately to 2.4 and 5.0 kb) encode a protein of approximately 22 kDa. In contrast to several other members of the FGF family, KGF has a signal peptide and is actively secreted. Cellular response to KGF is mediated by a specific receptor that is transcribed from an alternately spliced variant of the FGF type 2 receptor (FGFR-2). KGF transcripts have been detected in prostatic tissues and in stromal cells cultured from rat and human prostates as well as in a variety of stromal cells derived from other organs. Prostatic epithelial cells and numerous other types of epithelial cells are targets of KGF's mitogenic activity. Several factors involved in wound healing regulate the expression of KGF, but androgen regulation of KGF is of greatest relevance to the role of KGF in the prostate. Current efforts to localize and manipulate KGF activity in vivo should reveal the significance of KGF expression and function in the prostate and in other organs.
成纤维细胞生长因子（FGF）家族成员是重要的生长调节因子。在FGFs中，角质形成细胞生长因子（KGF）似乎具有独特的特性，这表明它是前列腺中的一种旁分泌因子。两种KGF转录本（约2.4和5.0 kb）编码一种约22 kDa的蛋白质。与FGF家族的其他几个成员不同，KGF有一个信号肽并被主动分泌。细胞对KGF的反应由一种特异性受体介导，该受体由FGF 2型受体（FGFR - 2）的一个选择性剪接变体转录而来。在前列腺组织、从大鼠和人类前列腺培养的基质细胞以及从其他器官衍生的多种基质细胞中都检测到了KGF转录本。前列腺上皮细胞和许多其他类型的上皮细胞是KGF有丝分裂活性的靶标。参与伤口愈合的几个因素调节KGF的表达，但KGF的雄激素调节与KGF在前列腺中的作用最为相关。目前在体内定位和操纵KGF活性的努力应能揭示KGF在前列腺和其他器官中的表达及功能的重要性。
