Bouchard C
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada.
Int J Obes Relat Metab Disord. 1995 Sep;19 Suppl 3:S10-3.
Attempts to define the genetic basis of obesity in the present century probably began with the study of Davenport. A number of papers were published on the topic based on weight for height data prior to the 1970s. Bray has summarized these studies which quite consistently demonstrated that obese children had frequently obese parents. Following this period, the field of genetic epidemiology began to contribute new methods and research strategies in the efforts to define the genetic basis of quantitative multifactorial phenotypes. For the past 15 years or so, a good number of reports have been published regarding the heritability level and the segregation pattern of body mass for stature, and other indicators of obesity. These studies have been summarized recently. The focus of this report is on animal and human studies providing evidence for a role of specific genes in human variation for indicators of obesity.
本世纪对肥胖症遗传基础的研究尝试可能始于达文波特的研究。在20世纪70年代之前，就有一些基于身高体重数据的相关论文发表。布雷总结了这些研究，这些研究相当一致地表明肥胖儿童的父母往往也肥胖。在此之后，遗传流行病学领域开始贡献新的方法和研究策略，以确定多因素定量表型的遗传基础。在过去大约15年里，已经发表了大量关于身高体重指数以及其他肥胖指标的遗传度水平和分离模式的报告。最近对这些研究进行了总结。本报告的重点是动物和人类研究，这些研究为特定基因在人类肥胖指标变异中的作用提供了证据。
