Starzyński Z, Marek K, Kujawska A, Szymczak W
Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Int J Occup Med Environ Health. 1995;8(3):223-9.
Mortality study was carried out on the cohort of 11,224 men with coal workers' pneumoconiosis or silicosis diagnosed during the period 1970-1985. The cohort was selected from the register of occupational diseases and was traced up to the end of 1991. The general male population of Poland was a reference group. The study showed small but significant excess of total mortality (SMR = 115; p < 0.01). The analysis of death causes revealed an elevated mortality from infectious diseases, among which tuberculosis was most prevalent (SMR = 212; p < 0.01) and from pneumoconioses predominant in diseases of the respiratory system, (SMR = 426; p < 0.01) and lung cancer (SMR = 116; p < 0.01). The comparison of the prevalence of smoking in the population under study with that in the reference general male population of Poland indicated that this habit is mostly responsible for the excess of lung cancer deaths. This finding contradicts the hypothesis that there is a causal relationship between exposure to dusts containing crystalline silica, pneumoconiosis and lung cancer.
对1970 - 1985年期间确诊为煤工尘肺或矽肺的11224名男性队列进行了死亡率研究。该队列选自职业病登记册,随访至1991年底。波兰男性总人口作为参照组。研究显示总死亡率虽略有升高但差异显著(标准化死亡比SMR = 115;p < 0.01)。死因分析显示,传染病死亡率升高,其中结核病最为常见(SMR = 212;p < 0.01),呼吸系统疾病中以尘肺病为主的疾病死亡率升高(SMR = 426;p < 0.01),肺癌死亡率也升高(SMR = 116;p < 0.01)。将研究人群与波兰男性总人口中的吸烟率进行比较表明,这种习惯是肺癌死亡人数过多的主要原因。这一发现与接触含结晶二氧化硅粉尘、尘肺病和肺癌之间存在因果关系的假设相矛盾。