Tokumura A, Yotsumoto T, Masuda Y, Tanaka S
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Res Commun Mol Pathol Pharmacol. 1995 Oct;90(1):96-102.
Intravenous injection of lysophosphatidic acid (LPA, 1-acyl-sn-glycerol-3-phosphate) into conscious, spontaneously hypertensive rats (SHR) promptly elicited hypertension in a dose-dependent manner, its effect being significantly higher than in conscious, age-matched Wistar Kyoto strain rats (WKY). There was, however, no difference between the potencies of LPA in raising the mean blood pressure of SHR and WKY anesthetized with pentobarbital. The releases of norepinephrine, angiotensin II, prostaglandin and leukotriene were found not to be involved in the vasopressor effect of LPA in SHR, although thromboxane seemed to be slightly related to the action of LPA.
向清醒的自发性高血压大鼠（SHR）静脉注射溶血磷脂酸（LPA，1-酰基-sn-甘油-3-磷酸）能迅速以剂量依赖的方式引发高血压，其作用显著高于清醒的、年龄匹配的Wistar Kyoto品系大鼠（WKY）。然而，LPA升高戊巴比妥麻醉的SHR和WKY平均血压的效力之间没有差异。研究发现，去甲肾上腺素、血管紧张素II、前列腺素和白三烯的释放与LPA在SHR中的升压作用无关，尽管血栓素似乎与LPA的作用略有相关。
