Diacinti D, Acca M, D'Erasmo E, Tomei E, Mazzuoli G F
II Clinica Medica, Policlinico Umberto I, University of Rome La Sapienza, Italy.
Calcif Tissue Int. 1995 Dec;57(6):426-9. doi: 10.1007/BF00301945.
We analyzed the vertebral morphometry of healthy premenopausal women and their changes with age and menopause in order to better define the reference population for the clinical and epidemiological evaluation of vertebral fractures. Vertebral morphometry has been performed on lateral thoracic and lumbar spine films from 50 premenopausal and 76 postmenopausal normal women, age range 39-74 years. Vertebral heights and the anterior height/posterior height ratio are significantly lower in postmenopausal compared with premenopausal women. Vertebral anterior height decreases about 1.5 mm/year, whereas middle and posterior height decreases about 1.3 and 1.2/mm year, respectively. A statistically significant reduction of vertebral heights by around 1 mm/vertebra was observed in postmenopausal (n = 16) compared with premenopausal women (n = 20) of the same age (P < 0.05). The results demonstrate that vertebral heights are lower with advancing age and menopause and that the vertebral heights difference in elderly people is not only the consequence of a cohort effect. The results also contribute to better defining the reference population to be chosen for evaluating vertebral deformation.
我们分析了健康绝经前女性的椎体形态测量数据及其随年龄和绝经的变化，以便更好地界定用于椎体骨折临床和流行病学评估的参考人群。对年龄在39 - 74岁的50名绝经前和76名绝经后正常女性的胸椎和腰椎侧位片进行了椎体形态测量。绝经后女性的椎体高度和前高/后高比值显著低于绝经前女性。椎体前高每年下降约1.5毫米，而中高和后高分别每年下降约1.3毫米和1.2毫米。与同年龄的绝经前女性（n = 20）相比，绝经后女性（n = 16）的椎体高度在统计学上显著降低约1毫米/椎体（P < 0.05）。结果表明，椎体高度随着年龄增长和绝经而降低，并且老年人的椎体高度差异不仅是队列效应的结果。这些结果也有助于更好地界定用于评估椎体变形的参考人群。
