De Scheerder I K, Wilczek K L, Verbeken E V, Vandorpe J, Lan P N, Schacht E, Piessens J, De Geest H
Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
Cardiovasc Intervent Radiol. 1995 Jul-Aug;18(4):227-32. doi: 10.1007/BF00239417.
To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries.
Nonarticulated, stainless steel, slotted-tube stents were coated with 1) a biodegradable poly-(organo)phosphazene with aminoacid ester side groups and 2) a biostable polyurethane prepared from an amphiphilic polyether, diphenyl methane-4,4'-diisocyanate and butane diol as chain extender. The stents were deployed in porcine peripheral arteries using an oversized balloon.
The neonintimal response to amphiphilic polyurethane-coated stents was similar to the uncoated metallic stents. Poly(organo)phosphazene-coated stents, however, induced a severe histiolymphocytic and fibromuscular reaction resembling a foreign body reaction.
Amphiphilic polyurethane is very promising as a biocompatible stent coating. Poly-(organo)phosphazene, however, appears unsuitable for this purpose.
研究聚（有机）磷腈和两亲性聚氨酯涂层的超大尺寸不锈钢支架植入猪外周动脉后的新生内膜反应。
非关节型不锈钢开槽管支架分别用1）带有氨基酸酯侧基的可生物降解聚（有机）磷腈和2）由两亲性聚醚、二苯基甲烷-4,4'-二异氰酸酯和丁二醇作为扩链剂制备的生物稳定聚氨酯进行涂层处理。使用超大尺寸球囊将支架植入猪外周动脉。
两亲性聚氨酯涂层支架的新生内膜反应与未涂层的金属支架相似。然而，聚（有机）磷腈涂层支架引发了严重的组织淋巴细胞和纤维肌肉反应，类似于异物反应。
两亲性聚氨酯作为生物相容性支架涂层非常有前景。然而，聚（有机）磷腈似乎不适合用于此目的。
