Delanghe J, Duprez D, de Buyzere M, Robbrecht D, Bergez B, Leroux-Roels G, Clement D
Department of Clinical Chemistry, University Hospital, Gent, Belgium.
Eur Heart J. 1995 Sep;16(9):1269-76. doi: 10.1093/oxfordjournals.eurheartj.a061085.
The MN blood group has been linked with blood pressure levels and sodium-lithium counter-transport in red blood cells of normotensives. The aim of the study was to compare the distribution of MN phenotypes according to age at diagnosis of essential hypertension and to investigate the relationship between MN phenotypes, severity of complications and therapeutic needs. MN blood group polymorphism was studied in 386 Caucasians with established essential arterial hypertension, treated for at least one year. In 285 healthy normotensive blood donors, blood pressure was measured and MN blood group was typed. MN blood groups were typed with polyclonal antisera and confirmed with monoclonal antisera. MN blood group phenotype frequencies in hypertensives were 0.207 (MM), 0.601 (MN), and 0.192 (NN), which differs (P < 0.000002) from the distribution in the controls: 0.270 (MM), 0.540 (MN) and 0.189 (NN). The relative MN phenotype frequency was strongly over-represented (P < 0.05). Age at detection of hypertension was significantly lower for MN patients (P < 0.0005). With increasing age of detection, the relative frequency of MN phenotype gradually decreases from 0.73 in those detected before age 40 to 0.50 for patients detected after 60. This observation holds true for both male and female hypertensive. Furthermore, hypertensives with a MM blood group had a lower (P < 0.05) prevalence of cerebrovascular accidents. In controls, blood pressure was comparable for the three MN phenotypes. The present study suggests that the MN phenotype is a genetic factor associated with early detection of essential hypertension.
MN血型系统与血压水平以及正常血压者红细胞中的钠-锂逆向转运有关。本研究的目的是比较根据原发性高血压诊断年龄的MN血型表型分布，并研究MN血型表型、并发症严重程度和治疗需求之间的关系。对386名确诊为原发性动脉高血压且已接受至少一年治疗的白种人进行了MN血型多态性研究。对285名健康的正常血压献血者测量了血压并进行了MN血型分型。使用多克隆抗血清对MN血型进行分型，并用单克隆抗血清进行确认。高血压患者中MN血型表型频率分别为0.207（MM）、0.601（MN）和0.192（NN），与对照组分布（0.270（MM）、0.540（MN）和0.189（NN））不同（P<0.000002）。相对MN表型频率显著过高（P<0.05）。MN患者高血压检测时的年龄显著更低（P<0.0005）。随着检测年龄的增加，MN表型的相对频率从40岁之前检测出的患者中的0.73逐渐降至60岁之后检测出的患者中的0.50。这一观察结果在男性和女性高血压患者中均成立。此外，MM血型的高血压患者脑血管意外的患病率较低（P<0.05）。在对照组中，三种MN表型的血压相当。本研究表明，MN表型是与原发性高血压早期检测相关的遗传因素。
