Mena N B, Mathur R, Nayar U
Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Indian J Physiol Pharmacol. 1995 Oct;39(4):339-46.
The limbic system has been implicated in the modulation of pain. The aim of this study was to determine the role of amygdala in different types of pain, viz., phasic and tonic. Unilateral stimulation of central nucleus of amygdala (CeA), basolateral nucleus (BL) and medial amygdaloid (MeA) in conscious rats resulted in the reduction of the tonic formalin-induced pain. The thresholds for simple vocalization (SV) and vocalization after-discharge (VA) were elevated during amygdalar stimulation in the tail-flick (phasic pain) test. However, the threshold for tail-flick (TF) evoked by electric shock was not affected. Tail-flick latency (TFL) to noxious heat was accentuated during amygdalar stimulation. These results suggest that amygdala had a modulatory role in the descending endogenous pain control mechanisms.
边缘系统与疼痛调节有关。本研究的目的是确定杏仁核在不同类型疼痛（即相位性疼痛和持续性疼痛）中的作用。对清醒大鼠单侧刺激杏仁核中央核（CeA）、基底外侧核（BL）和内侧杏仁核（MeA）可减轻持续性福尔马林诱导的疼痛。在甩尾（相位性疼痛）试验中，杏仁核刺激期间简单发声（SV）和发声后放电（VA）的阈值升高。然而，电击诱发的甩尾（TF）阈值不受影响。杏仁核刺激期间，对有害热的甩尾潜伏期（TFL）延长。这些结果表明，杏仁核在下行性内源性疼痛控制机制中具有调节作用。
