Riederer A, Knipping S, Fischer A, Unger J
Klinik und Poliklinik für HNO-Kranke, Ludwig-Maximilians-Universität München.
HNO. 1995 Dec;43(12):724-7.
In addition to classic neurotransmitters, neuropeptides are believed to regulate functions of the nasal mucosa in man. The aim of this study was to localize the vasoactive neurotransmitter calcitonin gene-related peptide (CGRP) in different mucosal structures by immunocytochemical methods. Frozen sections of the inferior turbinates from 12 patients were incubated with antibodies to CGRP and immunocomplexes were visualized by the ABC (Avidin-Biotin-Complex) method. CGRP-positive nerve fibers were demonstrated in the adventitia of arteries and arterioles. Immunoreactions were also found in interstitial spaces and around ducts of seromucous glands. Additional immunoreactions were detectable in subepithelial nerves and mast cells. These morphologic findings indicate that CGRP may participate in the transmission of sensory stimuli, in vasoregulation and in allergic reactions. The occurrence of CGRP in the different anatomic structures suggests multiple roles of this neuropeptide in the nasal mucosa of man.
除了经典神经递质外，人们认为神经肽可调节人体鼻黏膜的功能。本研究的目的是通过免疫细胞化学方法在不同的黏膜结构中定位血管活性神经递质降钙素基因相关肽（CGRP）。对12例患者下鼻甲的冰冻切片用抗CGRP抗体进行孵育，并通过ABC（抗生物素蛋白-生物素复合物）法使免疫复合物可视化。在动脉和小动脉的外膜中发现了CGRP阳性神经纤维。在浆液性腺的间质间隙和导管周围也发现了免疫反应。在基底上皮神经和肥大细胞中也可检测到额外的免疫反应。这些形态学发现表明，CGRP可能参与感觉刺激的传递、血管调节和过敏反应。CGRP在不同解剖结构中的存在表明这种神经肽在人体鼻黏膜中具有多种作用。
