Strauss R G
Department of Pathology and Pediatrics, University of Iowa College of Medicine, Iowa City 52242-1182, USA.
J Clin Apher. 1995;10(3):114-8. doi: 10.1002/jca.2920100303.
The literature pertaining to the use of granulocyte transfusions as treatment for progressive bacterial, yeast, and fungal infections in severely neutropenic patients is reviewed. Efficacy in treating bacterial infections that are unresponsive to antimicrobial therapy is well established--especially if bone marrow failure does not recover rapidly and neutropenia is persistent. The role of therapeutic granulocyte transfusions for yeast and fungal infections has potential merit, but current data are incomplete and findings are inconsistent. The possibility of greater success has been raised by use of recombinant granulocyte colony stimulating factor to greatly increase the yield of neutrophils collected from normal donors.
本文综述了有关使用粒细胞输注治疗严重中性粒细胞减少患者的进行性细菌、酵母和真菌感染的文献。粒细胞输注在治疗对抗菌治疗无反应的细菌感染方面的疗效已得到充分证实——尤其是在骨髓衰竭未迅速恢复且中性粒细胞减少持续存在的情况下。治疗性粒细胞输注对酵母和真菌感染的作用具有潜在价值，但目前的数据不完整且结果不一致。使用重组粒细胞集落刺激因子极大地提高从正常供体采集的中性粒细胞产量，增加了取得更大成功的可能性。
