Smithson J E, Radford-Smith G, Jewell G P
Gastroenterology Unit, Radcliffe Infirmary, Oxford, U.K.
J Clin Gastroenterol. 1995 Dec;21(4):283-6. doi: 10.1097/00004836-199512000-00006.
Recent reports of reduced appendectomy rates in patients with ulcerative colitis have not distinguished between primary appendectomy (surgery for appendicitis) and incidental appendectomy (removal of the appendix for other reasons). In the present case control study, we examined the frequency of primary appendectomy in subjects with ulcerative colitis (n = 197) and Crohn's disease (n = 117) compared to a control group of dermatology outpatients (n = 243). A reduced rate of primary appendectomy was found in the ulcerative colitis group (adjusted odds ratio 0.20, 95% confidence intervals 0.070-0.53, p < 0.0005) but not in the Crohn's disease patients (adjusted odds ratio 0.93, 95% confidence intervals 0.39-2.18, p = NS). These data suggest that appendicitis occurs less commonly than would be expected in individuals who develop ulcerative colitis. Environmental or immunoregulatory factors may be responsible. Tonsillectomy rates were also examined in each study group, but no overall differences were found between patients with inflammatory bowel disease and controls.
近期关于溃疡性结肠炎患者阑尾切除术率降低的报告并未区分原发性阑尾切除术（针对阑尾炎的手术）和附带阑尾切除术（因其他原因切除阑尾）。在本病例对照研究中，我们将溃疡性结肠炎患者（n = 197）和克罗恩病患者（n = 117）与皮肤科门诊对照组患者（n = 243）进行比较，研究原发性阑尾切除术的频率。结果发现，溃疡性结肠炎组原发性阑尾切除术率降低（调整后的优势比为0.20，95%置信区间为0.070 - 0.53，p < 0.0005），但克罗恩病患者中未出现这种情况（调整后的优势比为0.93，95%置信区间为0.39 - 2.18，p = 无显著性差异）。这些数据表明，在患溃疡性结肠炎的个体中，阑尾炎的发生率低于预期。环境或免疫调节因素可能是原因所在。我们还对每个研究组的扁桃体切除术率进行了检查，但炎症性肠病患者与对照组之间未发现总体差异。
