Cruz I, Cruz M E, Carrasco F, Horton J
Ecuadorean Academy of Neurosciences, Quito, Ecuador.
J Neurol Sci. 1995 Nov;133(1-2):152-4. doi: 10.1016/0022-510x(95)00181-z.
Albendazole has been used successfully in the treatment of cerebral cysticercosis for several years. The published dosage schedule has varied from 15 mg/kg/day for 8 days to up to 30 days. Fifty three patients with neurocysticercosis received 8, 15 or 30 days treatment with 800 mg of albendazole daily. The present study demonstrates the effectiveness in clinical and radiological terms of albendazole 800 mg/day for 8 days for the majority of patients affected with cystic or encephalitic parenchymatous cysticercosis. There was no apparent advantage of continuation of treatment for 15 or 30 days in this series. The routine use of high dose steroids limited the effects of parasite destruction. No toxicity attributable to albendazole was encountered.
阿苯达唑已成功用于治疗脑囊尾蚴病数年。已公布的给药方案从每日15毫克/千克，持续8天到长达30天不等。53例神经囊尾蚴病患者接受了每日800毫克阿苯达唑治疗8天、15天或30天。本研究证明，对于大多数患有囊性或脑实质型囊尾蚴病的患者，每日800毫克阿苯达唑治疗8天在临床和影像学方面是有效的。在本系列研究中，持续治疗15天或30天没有明显优势。常规使用高剂量类固醇限制了寄生虫破坏的效果。未发现阿苯达唑所致的毒性反应。
