Schurch B, Hauri D, Rodic B, Curt A, Meyer M, Rossier A B
Swiss Paraplegic Centre, Clinic Balgrist, Zurich University, Switzerland.
J Urol. 1996 Mar;155(3):1023-9. doi: 10.1016/s0022-5347(01)66376-6.
The paralytic effect of botulinum-A toxin injections on the external urethral sphincter was investigated prospectively in patients with neurogenic voiding disorders.
Transurethral versus transperineal botulinum-A toxin injections were performed in 24 spinal cord injury male patients with detrusor-sphincter dyssynergia and the respective efficacy was compared.
In 21 of 24 patients detrusor-sphincter dyssynergia was significantly improved with a concomitant decrease in post-void residual volumes in most cases. Botulinum-A toxin effects lasted 3 to 9 months, making reinjections necessary.
Although costly, botulinum-A toxin injections, which aim at suppressing detrusor-sphincter dyssynergia but not bladder neck dyssynergia, appear to be a valid alternative for patients who do not desire surgery or are unable to perform self-catheterization.
对神经源性排尿障碍患者前瞻性地研究A型肉毒毒素注射对外尿道括约肌的麻痹作用。
对24例患有逼尿肌-括约肌协同失调的脊髓损伤男性患者进行经尿道与经会阴A型肉毒毒素注射，并比较各自的疗效。
24例患者中有21例逼尿肌-括约肌协同失调得到显著改善，多数病例排尿后残余尿量随之减少。A型肉毒毒素的作用持续3至9个月，因此需要再次注射。
尽管成本高昂，但旨在抑制逼尿肌-括约肌协同失调而非膀胱颈协同失调的A型肉毒毒素注射，对于不希望手术或无法进行自我导尿的患者而言似乎是一种有效的替代方法。
