甘氨酸和γ-氨基丁酸与猫脑6个区域突触体组分的“结合”；士的宁的作用
'Binding' of glycine and gamma-aminobutyric acid to synaptosomal fractions of 6 regions of the feline brain; effects of strychnine.
作者信息
DeFeudis F V, Madtes P, Gervas-Camacho J
出版信息
Experientia. 1977 Mar 15;33(3):340-2. doi: 10.1007/BF02002816.
GABA (6 X 10(-6) M) binding to synaptosome-enriched fractions of cat CNS exhibited a clear rostro-caudal gradient, whereas glycine (6 X 10(-6) M) binding was greatest to particles of cerebellar cortex, and this was followed by medulla approximately equal to caudate nucleus larger than or equal to cerebral cortex larger than or equal to pons larger than corona radiata. Strychnine-SO4 (10(-3) or 10(-4) M) inhibited the binding of GABA and glycine in all brain regions studied; at 10(-5) M this drug inhibited the binding of both GABA and glycine only to particles of the cerebral cortex.
γ-氨基丁酸（6×10⁻⁶ M）与猫中枢神经系统富含突触体的部分结合呈现出明显的头尾梯度，而甘氨酸（6×10⁻⁶ M）与小脑皮质颗粒的结合最强，其次是延髓，其结合量约等于尾状核，大于或等于大脑皮质，大于或等于脑桥，大于辐射冠。硫酸士的宁（10⁻³或10⁻⁴ M）在所有研究的脑区中均抑制γ-氨基丁酸和甘氨酸的结合；在10⁻⁵ M时，该药物仅抑制γ-氨基丁酸和甘氨酸与大脑皮质颗粒的结合。
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