脊椎动物γ-氨基丁酸受体
Vertebrate GABA receptors.
作者信息
DeFeudis F V
出版信息
Neurochem Res. 1978 Jun;3(3):263-80. doi: 10.1007/BF00965574.
PMID:370671
Abstract
Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake) receptors in the presence of Na+.
摘要
体内和组织培养的生理药理学研究表明，脊椎动物中枢神经系统中存在突触GABA受体。即使在存在和不存在Na+的情况下，GABA拮抗剂荷包牡丹碱均可用于检测突触GABA受体，尽管在存在Na+的情况下，GABA与脑亚细胞组分的结合主要发生在转运（摄取）受体上。
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